我们观察过川芎Ⅲ号碱对鼠肝线粒体氧化磷酸化和能量生成的作用。结果表明:该化合物降低鼠肝线粒体氧耗量,减少ATP的生成,并有解偶联作用。 线粒体电子传递链组成和偶联磷酸化多酶体系镶嵌在内膜脂质双层中。显然,膜结构的变化,会引起暎流动性和功能的改变,直接影响电子传递和偶联磷酸化反应,并使一些小分子物质的通透性发生紊乱。文献指出:Ca~(2+)是调节细胞内能量转换的主要离子,对丙酮酸 We observed the effect of Chuanxiong Ⅲ alkali on oxidative phosphorylation and energy production of rat liver mitochondria. The results showed that the compound can reduce the mitochondrial oxygen consumption of rat liver, reduce the production of ATP and have the effect of uncoupling. Mitochondrial electron transport chain composition and coupled phosphorylated multizyme system inlaid in the intima-lipid bilayer. Obviously, the changes of the membrane structure will lead to changes in mapping fluidity and function, which directly affect electron transfer and coupling phosphorylation reactions, and disturb the permeability of some small molecules. The literature states: Ca ~ (2+) is the main ion regulating intracellular energy conversion, pyruvate