论文部分内容阅读
目的:探讨长春新碱注射剂致不良反应的一般规律及特点,指导临床合理用药。方法:通过检索1994～2006年国内公开发行的医学期刊报道应用长春新碱注射剂致不良反应案例,并进行统计分析。结果:不良反应多发生于<20a和>60a年龄组,女性多于男性,其出现时间可发生于用药后的各个时间段。不良反应临床表现复杂多样,涉及机体多个器官、系统损伤,尤其是对胃肠的损伤。结论:临床医师、药师应了解长春新碱注射剂所致不良反应的规律和特点,加强其应用的监测,以减少不良反应的发生。
Objective: To investigate the general rules and characteristics of adverse reactions caused by vincristine injection and to guide clinical rational use of drugs. Methods: The cases of adverse reactions induced by vincristine injection were reported by medical journals published from 1994 to 2006 in China, and statistical analysis was made. Results: Adverse reactions occurred mostly in <20a and> 60a age groups, with more females than males, and their appearance time could occur at various time points after treatment. Adverse reactions are complex and diverse clinical manifestations involving multiple organs of the body, systemic damage, especially gastrointestinal damage. Conclusion: Clinicians and pharmacists should understand the regularities and characteristics of adverse reactions caused by vincristine injection and strengthen the monitoring of their application to reduce the incidence of adverse reactions.