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1927年Lewis T 开始研究免疫与神经内分泌的关系。1977年Besedovsky提出免疫-神经-内分泌网络学说,指出免疫系统与神经内分泌系统存在着完整的调节环路。本文对免疫与下丘脑-垂体-甲状腺轴的关系作一综述,探讨其理论意义和实用价值。一、下丘脑-垂体-甲状腺轴对免疫的影响神经系统对免疫的影响早年曾发现机体的免疫器官如胸腺、骨髓、脾脏、淋巴结等都有神经分布,这为神经系统调节免疫反应提供了形态学基础。神经损伤可明显降低骨髓细胞、胸腺和脾脏细胞的数量和功能,间接证明存在这种调节作用。李求是等发现小鼠左侧脑皮质部分切除后,脾细胞的NK细胞毒及IL2产生能力
1927 Lewis T began to study the relationship between immune and neuroendocrine. In 1977, Besedovsky proposed the immune-neuroendocrine network theory, pointing out that there is a complete regulatory loop between the immune system and the neuroendocrine system. This article reviews the relationship between immunity and hypothalamus-pituitary-thyroid axis, and discusses its theoretical significance and practical value. First, the hypothalamus - pituitary - thyroid axis immune effects Nervous system on the immune response Earlier discovered the body’s immune organs such as thymus, bone marrow, spleen, lymph nodes and so has a nerve distribution, which provides the nervous system to regulate the immune response morphology Fundamentals of learning. Nerve injury can significantly reduce the number and function of bone marrow cells, thymus and spleen cells, an indirect proof of the existence of this regulatory role. Li Qiu found mice left cortex partial resection, NK cell cytotoxicity of spleen cells and IL2 production capacity