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【目的】观察经新生儿疾病筛查程序诊治的先天性甲状腺功能减低症(congential hypothyroidism,CH)患儿骨密度状况,分析疾病本身及治疗因素对骨密度的影响。【方法】以1～2岁CH患儿30例为研究对象,检测骨密度值,与正常儿童比较,并分析其影响因素。【结果】CH组骨密度与正常对照组比较差异无统计学意义,与甲状腺组织发育情况及诊断时血清游离甲状腺素(free unbound thyroxin,FT4)水平有相关性。【结论】CH患儿治疗后骨密度可达正常水平,甲状腺组织发育情况及诊断时FT4水平是影响骨密度的重要因素。
【Objective】 To observe the bone mineral density (BMD) in children with congenital hypothyroidism (CH) diagnosed and treated by neonatal screening program and to analyze the influence of the disease and the therapeutic factors on BMD. 【Methods】 Thirty children aged 1 ~ 2 years old with CH were enrolled in this study. The bone mineral density (BMD) was measured and compared with that of normal children. The influencing factors were also analyzed. 【Results】 The bone mineral density in CH group was not significantly different from that in normal control group, which was correlated with the development of thyroid tissue and the level of serum free unbound thyroxin (FT4) at diagnosis. 【Conclusion】 The bone mineral density in children with CH up to normal levels, thyroid tissue development and diagnosis of FT4 levels are important factors affecting bone mineral density.