最近有人从严重恶性黑素瘤患者的尿中发现一种肿瘤特异性蛋白。本文作者用荧光抑制技术亦检查出同样的黑素瘤特异性尿蛋白(MSP),并证明它可在黑素瘤的早期发现,且还见于发展中的晕痣。尿MSP的阳性率随恶性黑素瘤的扩展而增高(Ⅲ期患者,阳性率达83%)。MSP的检出是借助其抑制黑素瘤细胞浆特异性抗血清的能力,因此,它可能与黑素细胞成分有关。在长期存活而无临床复发征象的黑素瘤患者以及晕痣患者中亦可显阳性,这表明MSP的释出,除细胞死亡外还有别的机理。一是,细胞表面和内部有相同的成分,有人认为红细胞的糖蛋白就是这样。作者所用的异种抗血清除有抗胞浆活性外,还能使胞膜着色(低滴度)。二 Recently, a tumor-specific protein was discovered in the urine of patients with severe malignant melanoma. The authors also examined the same melanoma-specific urinary protein (MSP) using fluorescence suppression technology and demonstrated that it can be found early in melanoma and also in the development of syncope. The positive rate of urinary MSP increased with the expansion of malignant melanoma (in stage III patients, the positive rate was 83%). The detection of MSP was based on its ability to inhibit melanoma cell-plasmid-specific antiserum and, therefore, it may be related to the composition of melanocytes. It is also positive in patients with melanoma who have long-term survival without clinical signs of recurrence and syncope, suggesting that MSP is released and there are other mechanisms besides cell death. One is that the cell surface and the inside have the same composition, and some people think that the erythrocyte glycoprotein is like this. The xenogeneic anti-blood scavenger used by the author has anti-cytoplasmic activity and can also stain the membrane (low titer). two