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目的:探讨兔肺VX2移植瘤模型用于评估肺部肿瘤放射治疗效果的可行性。方法:12只兔肺VX2移植瘤模型行短期大剂量放疗,放疗前及放疗后第7天行18F-FDGPET及CT检查,以常规病理作为金标准。结果:兔肺VX2移植瘤放疗前PET显像,常规SUVmax为2.95±1.04,延迟SUVmax为3.58±1.32;放疗后第7天PET显像,常规SUVmax为1.47±0.36,延迟SUVmax为1.88±0.44。放疗后PET常规显像较放疗前18F-FDG代谢变化百分率下降60.48±5.66,PET延迟显像18F-FDG代谢变化百分率下降57.18±6.79。兔肺VX2移植瘤放疗前后PET常规显像SUV改变与放疗前后PET延迟显像的SUV改变均以t检验分析,放疗前后SUV变化有统计学意义。病理检查见肿瘤组织内大片凝固坏死。结论:兔肺VX2移植瘤模型短期大剂量放疗后行18F-FDGPET显像,其SUV显著降低,可在兔肺VX2移植瘤出现CT形态学改变之前早期评估兔肺VX2移植瘤对放射治疗的反应。
Objective: To investigate the feasibility of using rabbit lung VX2 xenograft model to evaluate the efficacy of radiotherapy for lung tumors. Methods: Twelve rabbits lung VX2 xenografts were treated with short-term high-dose radiotherapy. Before radiotherapy and 7 days after radiotherapy, 18F-FDG PET and CT were performed. The conventional pathology was used as the gold standard. Results: The PET images of rabbit lung VX2 xenografts before radiotherapy were 2.95 ± 1.04 and 3.58 ± 1.32 respectively. PET imaging was performed on the 7th day after radiotherapy. The conventional SUVmax was 1.47 ± 0.36 and the delayed SUVmax was 1.88 ± 0.44. The percentage of 18F-FDG metabolism decreased 60.48 ± 5.66 and the percentage of 18F-FDG metabolism decreased 57.18 ± 6.79 after radiotherapy. The change of SUV in conventional VUV imaging of rabbit lung VX2 tumor before and after radiotherapy was analyzed by t-test. The changes of SUV before and after radiotherapy were statistically significant. Pathological examination showed massive tumor necrosis. CONCLUSION: The 18F-FDG PET imaging of rabbit VX2 xenograft model after short-term high-dose radiotherapy can significantly reduce the SUV. The response to radiation therapy can be evaluated early in the early stage of VX2 xenograft in rabbits before CT morphological changes .