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合成药NO - 1886是脂蛋白脂肪酶 (LPL)的激动剂 ,能降低血浆甘油三酯 (TG)并升高高密度脂蛋白胆固醇 (HDL -c)水平。我们曾发现NO - 1886还具有降低血糖的作用。本研究主要观察NO - 1886对糖尿病兔胰岛素抵抗及 β -细胞功能方面的影响。用高糖高脂饲料诱导 ,使新西兰兔血浆葡萄糖升高 ,发生胰岛素抵抗。在高糖高脂饲料中添加 1%NO - 1886进行治疗。结果发现NO - 1886可抑制血清葡萄糖升高 ,经糖耐量和胰岛素敏感性试验检测 ,NO - 1886可保护胰岛素的急性相分泌 ,增强胰岛素对葡萄糖的清除能力。研究结果提示NO - 1886具有改善胰岛素抵抗、降低血糖的作用。
The synthetic drug NO - 1886, an agonist of lipoprotein lipase (LPL), decreases plasma triglyceride (TG) and increases high density lipoprotein cholesterol (HDL - c) levels. We have found that NO - 1886 also has a hypoglycemic effect. This study mainly observed the effect of NO - 1886 on insulin resistance and β - cell function in diabetic rabbits. Induction with high-sugar, high-fat diet, New Zealand rabbit plasma glucose, insulin resistance. Add 1% NO - 1886 to high sugar and high fat diet for treatment. The results showed that NO - 1886 could inhibit the increase of serum glucose, as measured by glucose tolerance test and insulin sensitivity test, NO - 1886 could protect the acute phase secretion of insulin and enhance the ability of insulin to remove glucose. The results suggest that NO - 1886 has the effect of improving insulin resistance and lowering blood sugar.