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目的研究分析恶性血液病患者粒细胞减少期住院期间的抗菌药物使用情况,为抗菌药物临床应用决策提供参考。方法对我院2009～2010年83例恶性血液病患者中性粒细胞减少期使用的抗菌药物品种、病原学检查、抗菌药物费用、应用例次、应用时间、用药频度(DDDs)、药物利用指数(DUI)及抗菌药物联合用药等进行回顾性分析,分析其应用合理性。结果 83例恶性血液病患者中,54例患者出现感染,感染率为65.06%,病原学检查阳性15例;81例应用了抗菌药物,使用最多的抗菌药物是头孢吡肟。DDDs排序前3位的药物主要包括注射用头孢吡肟、氟康唑注射液、亚胺培南西司他丁,DUI≤1的有14个,DUI>1的6个。结论本试验分析结果对恶性血液病患者中性粒细胞减少期的合理使用抗菌药物具有参考意义。
Objective To study the use of antimicrobial agents during hospitalization in patients with hematologic malignancies and to provide reference for the clinical application of antimicrobial agents. Methods The antimicrobial agents used in neutropenia in 83 patients with hematologic malignancies from 2009 to 2010 in our hospital, etiological examination, cost of antimicrobial agents, application cases, application time, frequency of drug use (DDDs), drug use Index (DUI) and antimicrobial drug combination were retrospectively analyzed and analyzed its application rationality. Results Of the 83 patients with hematologic malignancies, 54 patients were infected with the infection rate of 65.06% and 15 were positive for pathogenic test. The antibacterials were used in 81 patients and cefepime was the most used antibacterial drug. DDDs ranked the first three drugs mainly include injection of cefepime, fluconazole injection, imipenem cilastatin, DUI ≤ 1 of 14, DUI> 1 of 6. Conclusion The results of this study have reference value for the rational use of antimicrobial agents in neutropenia patients with hematologic malignancies.