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目的 文献证明,白细胞在缺血性脑血管病中起重要作用。本研究通过测定代表白细胞活性的血浆中炎性介质(如蛋白醇和细胞激动素)的浓度,观察急性缺血性脑血管病患者白细胞的活性。 方法 对120例急性缺血性脑血管病患者(72例缺血性卒中,48例TIA)和35名正常健康人,用酶联免疫吸附分析法测定其血浆中性粒细胞凝胶酶相关脂质素(NGAL)、中性粒细胞蛋白酶4(NP4)、肿瘤坏死因子(TNF)和可溶性TNF受体蛋白-1(sTNFR-1)浓度。 结果 与正常组比较,缺血性卒中(P<0.0001)和TIA(P<0.01)患者血浆中NGAL及NP4浓度均升高;sTNFR-1浓度仅在缺血性卒中时升高(P<0.04);血浆纤维蛋白原浓度与sTNFR-1(r=0.32;P=
Objective literature shows that leukocytes play an important role in ischemic cerebrovascular disease. In this study, the activity of leukocytes in patients with acute ischemic cerebrovascular disease was determined by measuring the concentration of inflammatory mediators (such as albumin and cytokinin) in the plasma representing leukocyte activity. Methods 120 patients with acute ischemic cerebrovascular disease (72 ischemic stroke, 48 TIA) and 35 normal healthy subjects were enrolled in this study. Plasma neutrophil gelatinase-associated lipids (NGAL), neutrophil proteinase 4 (NP4), tumor necrosis factor (TNF) and soluble TNF receptor protein-1 (sTNFR-1). Results Plasma levels of NGAL and NP4 increased in ischemic stroke (P <0.0001) and TIA (P <0.01) patients compared with those in normal controls. The concentration of sTNFR-1 increased only in ischemic stroke (P <0.04 ); Plasma fibrinogen concentration and sTNFR-1 (r = 0.32; P =