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目的探讨福建地区无症状性颈动脉狭窄患者危险因素及对血清生物标记物表达的影响。方法采用横断面研究,以2013年1月~2014年6月福建地区心脑血管病高危人群269例为研究对象,根据颈动脉彩色多普勒超声检查结果分为颈动脉狭窄组25例(颈动脉狭窄≥50%),对照组244例(颈动脉狭窄0~49%),采用ELISA测定研究对象血清基质金属蛋白酶(MMP)-1,MMP-7、白细胞介素8和高敏C反应蛋白水平,分析各组间血管危险因素以及炎性生物标记物表达的差异。结果颈动脉狭窄组年龄、脑卒中家族史和高血压比例明显高于对照组(P<0.05,P<0.01)。颈动脉狭窄组血清MMP-1和MMP-7水平明显高于对照组[(160.63±34.88)μg/Lvs(105.39±14.06)μg/L,P=0.000;(16.38±0.88)μg/L vs(15.73±0.92)μg/L,P=0.003)]。结论合并年龄增长、高血压和脑卒中家族史3个危险因素的个体应注重颈动脉狭窄的早期筛查和防治。
Objective To investigate the risk factors of asymptomatic carotid artery stenosis in Fujian and its effect on serum biomarker expression. Methods A cross-sectional study was conducted. From January 2013 to June 2014, 269 high risk patients with cardiovascular and cerebrovascular diseases in Fujian were studied. According to the results of carotid color Doppler ultrasound, 25 patients with carotid stenosis (neck Arterial stenosis≥50%), 244 cases in the control group (0-49% carotid stenosis). Serum levels of matrix metalloproteinase (MMP) -1, MMP-7, interleukin 8 and high-sensitivity C-reactive protein The differences of vascular risk factors and inflammatory biomarkers between groups were analyzed. Results The age, family history of stroke and hypertension in carotid stenosis group were significantly higher than those in control group (P <0.05, P <0.01). Serum levels of MMP-1 and MMP-7 in carotid stenosis group were significantly higher than those in control group [(160.63 ± 34.88) μg / L vs (105.39 ± 14.06) μg / L, P = 0.000; 15.73 ± 0.92) μg / L, P = 0.003)]. Conclusion Individuals with age, hypertension, and family history of stroke should pay attention to early screening and prevention of carotid artery stenosis.