酮康唑为合成的咪唑二恶烷衍生物,对皮真菌及双相真菌均具有抑菌和杀菌活性。主要抑制真菌为麦角甾醇生物合成,能改变细胞膜其他脂类化合物的组成,与真菌细胞色素P—450酶系的结合力结合,从而抑制麦角甾醇合成,使膜结合酶的功能发生改变和膜的通透性改变、以致影响细胞内一些物质如钾离子、磷酸、氨基酸 Ketoconazole is a synthetic imidazole dioxane derivative, which has antibacterial and bactericidal activities against both dermatophytes and biphasic fungi. The main inhibitory fungi ergosterol biosynthesis can change the composition of other lipid compounds on the cell membrane, combined with the binding capacity of the fungal cytochrome P-450 enzyme system, thereby inhibiting the synthesis of ergosterol, the function of membrane-bound enzyme changes and membrane Permeability changes, so that the impact of some substances within the cell such as potassium, phosphoric acid, amino acids