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用放射免疫法测定原发性肝癌， 乙型肝炎， 肝硬化患者及正常人共２４０例血浆前列腺素Ｅ２ （ＰＧＥ２） 的水平。结果发现： 原发性肝癌（ＰＨＣ） 组ＰＧＥ２水平明显高于其他各组（ Ｐ＜０－０１）。而其他三组， 即对照组与良性肝病组相互间ＰＧＥ２ 无统计学意义（ Ｐ＞０－０５）。提示与正常人乃至良性肝病患者相比，ＰＨＣ患者体内ＰＧＥ２ 的合成变化较大， 说明ＰＧＥ２ 的增多与ＰＨＣ之间可能存在着内在联系。监测血浆ＰＧＥ２ 水平， 对ＰＨＣ的诊断、治疗及预后具有一定的应用价值。
A total of 240 plasma prostaglandin E2 (PGE2) levels were measured in patients with primary liver cancer, hepatitis B, cirrhosis, and normal controls by radioimmunoassay. The results showed that PGE2 levels in the primary liver cancer (PHC) group were significantly higher than those in other groups (P<0-01). The other three groups, the control group and the benign liver disease group, had no significant difference in PGE2 (P>0-05). It is suggested that the synthesis of PGE2 in PHC patients has a greater change than that of normal or benign liver diseases, suggesting that there may be an intrinsic link between the increase of PGE2 and PHC. Monitoring plasma PGE2 levels has a certain application value for the diagnosis, treatment and prognosis of PHC.