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1.给小白鼠预先腹腔注射乙素旋光异构体、四氢小蘖碱各40毫克/公斤,均能协同阈剂量1.0—1.2毫克/公斤士的宁的惊厥。将士的宁降为阈下剂量(0.8毫克/公斤),上述药物增大剂量到80或180毫克/公斤,剂量越大,协同士的宁惊厥作用则越明显。因此,设想它们的中枢抑制作用与协同士的宁惊厥的关系是较复杂。2.用脊猫试验时,刺激腓神经,记录胫前肌的反射活动,分别静脉注射消旋乙素30—40毫克/公斤、左旋乙素15—40毫克/公斤后,反射活动受到抑制,等剂量的右旋乙素或四氢小蘖碱无明显的抑制作用。消旋乙素常常有短时的兴奋现象,右旋乙素也有之。3.在脊猫的腹根记录反射放电时,静脉注射药物40毫克/公斤,观察到左旋乙素均抑制单、多突触放电活动;而右旋体仅有短时兴奋,增强单突触反射放电。消旋乙素先有短时兴奋,随之有抑制现象。四氢小蘗碱的作用不明显。本文资料说明,消旋乙素对脊髓活动的作用,包括了右旋体的短时兴奋和左旋体的中枢抑制作用。但应该指出,左旋乙素对脊髓水平的抑制作用,不及对脊髓以上脑部位为强。
1. To mice preperitoneal injection of B isomers of optical isomer, each of 40 mg / kg of berberine, can cooperate with the threshold dose of 1.0-1.2 mg / kg strychnine seizures. The soldiers of Ning down to the subthreshold dose (0.8 mg / kg), the dose of the above drugs to 80 or 180 mg / kg, the greater the dose, the synergist Ning convulsive effect is more pronounced. Therefore, it is more complicated to assume that their central inhibitory effect is related to the Sympathysynodymic convulsions. 2. With ridge cat test, the stimulation of the peroneal nerve, recording anterior tibialis reflex activity, respectively, intravenous injection of racemic B 30-40 mg / kg, L-B 15-40 mg / kg, reflex activity was inhibited, Equal doses of dextran or tetrahydrobiopterine no significant inhibitory effect. Racemic B is often a short-term excitement, dextrose B also has. 3. In the cat litter cat litter recording reflex discharge, the intravenous injection of drug 40 mg / kg, were observed levulopixin inhibit single and multiple synaptic discharge activity; and dextral only short-term excitement, enhanced monosynapses Reflected discharge. Racemic B first short-term excitement, followed by inhibition. The role of tetrahydrobiopberine is not obvious. This data shows that the role of racemic B on spinal cord activity, including the right dextrorotatory short-term excitement and central inhibition of levorotatory body. However, it should be pointed out that levulopalin inhibits the spinal level less than the upper brain area of the spinal cord.