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美国明尼苏达大学共济会癌瘤中心医师William J M Hruskesky在美国临床肿瘤学会的年会上报告说,每天化疗的用药时间对毒性有明显的影响。对膀胱癌或卵巢癌病人给与阿霉素和顺铂的随机研究表明,午前6点给与阿霉素比午后6点给药对肾脏的毒性小。他说,在并发症方面,给药时间的间隔和减少剂量方面,均有很大的差异,这决定于给药时间的早晚。现在仍需继续研究,因为许多化学治疗家有一种偏见,认为治疗效果好,就必定有毒性。我们不知道是否病人忍受的毒性越大,治疗效果也越大,否则疗效差。
William J M Hruskesky, MD, of the Cancer Center of the Freemasonry Center at the University of Minnesota, reported at the annual meeting of the American Society of Clinical Oncology that the daily chemotherapy time has a significant effect on toxicity. A randomized study of adriamycin and cisplatin given to patients with bladder or ovarian cancer showed that administration of doxorubicin at 6 o’clock in the afternoon was less toxic to the kidney than at 6 o’clock in the afternoon. He said that in terms of complications, there is a big difference in the interval between administration and the dose reduction, depending on the timing of administration. It is still necessary to continue to study because many chemotherapists have a prejudice that if they are effective, they must be toxic. We do not know whether the more toxic the patient is tolerated, the greater the therapeutic effect, or the poor efficacy.