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目的:探讨更年期妇女雌二醇水平与胰岛素抵抗的相关性。方法:采用病例对照方法,应用放射免疫测定方法和己糖激酶法对吉林大学第二医院妇女健康俱乐部成员中的年龄40～55周岁、腰围≥80cm者和腰围<80cm者各50例进行血清雌二醇、胰岛素、血糖测定。结果:腰围、BMI、WHR与血清雌二醇无相关性;雌二醇与HOMA-IR呈负相关,其组间差异有显著性。结论:更年期妇女腰围、BMI、WHR的增加与雌二醇水平无关;更年期妇女胰岛素抵抗的发生与血清雌激素水平降低有关。妇女若在绝经前及绝经早期恰当补充雌激素可减少胰岛素抵抗的发生,对降低更年期妇女糖尿病发病率、提高她们的生命质量有重要意义。
Objective: To investigate the correlation between estradiol level and insulin resistance in menopausal women. Methods: A case-control study was conducted. Radioimmunoassay and hexokinase assays were performed on 50 women aged 40-55 years with a waist circumference ≥ 80 cm and waist circumference <80 cm in the Women’s Health Club of the Second Hospital of Jilin University. Alcohol, insulin, blood glucose determination. Results: There was no correlation between waist circumference, BMI, WHR and serum estradiol. There was a negative correlation between estradiol and HOMA-IR, and the difference between the two groups was significant. Conclusion: The increase of waist circumference, BMI and WHR in menopause women has nothing to do with the level of estradiol. The incidence of insulin resistance in menopausal women is related to the decrease of serum estrogen level. Women in the pre-menopausal and early menopause proper estrogen can reduce the incidence of insulin resistance, reduce the incidence of diabetes in menopausal women, improve their quality of life of great significance.