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目的：探讨血浆置换术在重度妊高征治疗中的临床应用。方法：选择重度妊高征，妊娠３３周以后，临床治疗一周效果不明显的患者５例。用美国ＣＳ－３０００血细胞分离机进行血浆置换术。置换总量１０００～１６００ｍｌ，总置换时间２～４小时。置换液为新鲜血浆１０００～１６００ｍｌ，血小板１６Ｕ。结果：血浆置换后，血浆免疫物质（ＩｇＧ除外），肾素，血管紧张素，醛固酮，血栓素，前列环素，血、尿β２－ＭＧ均降低。肝、肾功能的各项化验无变化，ＩｇＧ升高。结论：血浆置换术为重度妊高征的治疗提供了一种全新的、先进的方法，达到了缓解症状、延长孕周、提高围产儿存活率、母婴安全的目的。
Objective: To investigate the clinical application of plasmapheresis in the treatment of severe pregnancy-induced hypertension. Methods: Five patients with severe pregnancy-induced hypertension (PIH) were selected. After 33 weeks of gestation, there were 5 patients who had no obvious effect in one week of clinical treatment. Plasma exchange was performed using a U.S. CS-3000 blood cell separator. Total replacement of 1000 ~ 1600ml, the total replacement time of 2 to 4 hours. Replacement fluid is fresh plasma 1000 ~ 1600ml, platelet 16U. Results: After plasma exchange, plasma immune substances (except IgG), renin, angiotensin, aldosterone, thromboxane, prostacyclin, blood and urine β2-MG were decreased. Various tests of liver and kidney function did not change, IgG increased. Conclusion: Plasmapheresis provides a new and advanced method for the treatment of severe PIH, and has achieved the goal of alleviating symptoms, prolonging gestational age, improving the perinatal survival rate and maternal and infant safety.