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目的观察青年缺血性脑卒中患者血尿酸(UA)水平及其相关影响因素。方法连续收集2014年1月至2016年6月201例青年缺血性脑卒中住院患者作为观察组,收集同期体检中心的健康体检者202例作为健康组,分析比较两组的尿酸水平及其影响因素。结果青年缺血性脑卒中患者血尿酸水平显著高于对照组(P<0.05);两组间性别、吸烟、饮酒、高血压病、糖尿病、房颤、冠心病等比较差异有统计学意义(P<0.05);高密度脂蛋白(HDL)、三酰甘油(TG)、肌酐(CRE)、同型半胱氨酸(Hcy)比较差异有统计学意义(P<0.05)。性别、年龄、高血压、冠心病、吸烟、饮酒、UA、Hcy、TG、低密度脂蛋白(LDL)、血肌酐(Cre)等是青年缺血性脑卒中的独立危险因素(P<0.05)。神经功能缺损程度:轻度与中、重度组间比较差异有统计学意义(P<0.05),中度与重度组间比较差异未见统计学意义(P>0.05)。血尿酸水平与高血压(r=0.213,P=0.002)、Cre(r=0.392,P<0.001)之间呈正相关。结论血尿酸水平的升高是青年缺血性脑卒中的危险因素。
Objective To observe the level of serum uric acid (UA) in young patients with ischemic stroke and its related factors. Methods Totally 201 inpatients with ischemic stroke admitted from January 2014 to June 2016 were selected as the observation group and 202 healthy subjects at the same period were collected as the healthy group.The uric acid levels and their effects were compared between the two groups factor. Results The level of serum uric acid in young patients with ischemic stroke was significantly higher than that in the control group (P <0.05). There were significant differences in gender, smoking, drinking, hypertension, diabetes, atrial fibrillation and coronary heart disease between the two groups (P <0.05). There were significant differences in HDL, TG, CRE and Hcy between the two groups (P <0.05). Sex, age, hypertension, coronary heart disease, smoking, alcohol consumption, UA, Hcy, TG, LDL and Cre were independent risk factors of youth ischemic stroke (P < . The degree of neurological deficit: There was significant difference between mild and moderate and severe groups (P <0.05), but there was no significant difference between moderate and severe groups (P> 0.05). Serum uric acid levels were positively correlated with hypertension (r = 0.213, P = 0.002) and Cre (r = 0.392, P <0.001). Conclusion The elevated serum uric acid level is a risk factor for ischemic stroke in young people.