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免疫系统平衡的维持有赖于淋巴细胞成熟过程中抗原特异性克隆的选择性存活与凋亡。静止B细胞（naiveBcell）经CD40＆活可诱导Fas表达，Fas－Fas配体（FasL）的结合导致的激活B细胞的凋亡是防止抗原特异性克隆过分增殖的重要机制。而抗-Ig可部分保护B细胞免于Fas介导的凋亡，这
The maintenance of immune system balance depends on the selective survival and apoptosis of antigen-specific clones during lymphocyte maturation. The expression of Fas in naive Bcells induced by CD40 & live and the apoptosis of activated B cells induced by the binding of Fas-Fas ligand (FasL) are important mechanisms to prevent over-proliferation of antigen-specific clones. Whereas anti-Ig can partially protect B cells from Fas-mediated apoptosis