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组织病理诊断表明:本院外阴硬化萎缩性苔藓(硬萎)81例(82块标本)中充份发展的硬萎64例(65块标本),其表现为表皮萎缩,基底层液化变性,真皮浅层胶原纤维均质性变性,其下方有炎性细胞浸润。早期硬萎4例,表现为表皮萎缩,钉突消失,真皮浅层沿着表皮与真皮交界处有密集或带状淋巴细胞浸润。硬萎伴发慢性单纯苔藓13例,表现为表皮各层增厚,其余同充份发展的硬萎。超微结构观察:部分细胞间隙明显扩大,桥粒减少,上皮间有炎细胞浸润,基底细胞排列不规则,部分基底膜变薄;间质中胶原纤维排列紊乱,肿胀,横纹不明显。
Histopathological diagnosis showed that in our hospital, 64 cases (65 specimens) of sclerosis were fully developed in 81 cases (82 specimens) of vulvar and atrophic lichen sclerosis in our hospital, which showed epidermic atrophy, liquefaction of the basilar layer and dermis Superficial collagen fibers are denatured with inflammatory cell infiltration beneath them. 4 cases of early sclerosis, manifested as epidermal atrophy, nail disappeared, the superficial layer of dermis along the dermis and dermis at the junction of dense or ribbon-shaped lymphocyte infiltration. Thirteen cases of chronic mevlithiasis accompanied with sclerema showed thickening of all layers of the epidermis and the rest with the fully developed sclerenchyma. Ultrastructural observation: Part of the intercellular space was significantly expanded, reduced desmosomes, inflammatory cell infiltration between the epithelium, basal cells arranged irregularly, some of the basement membrane thinning; interstitial collagen fibers arranged disorder, swelling, horizontal stripes are not obvious.