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目的:比较Sextant微创经皮椎弓根螺钉内固定术与开放式椎弓根内固定术治疗胸腰椎多发脊柱骨折的临床效果。方法:选取2016年7月至2019年7月濮阳市人民医院收治的胸腰椎多发脊柱骨折患者60例，采用简单随机法分为开放组(28例)和微创组(32例)。开放组采用开放式椎弓根内固定术治疗，微创组采用Sextant微创经皮椎弓根螺钉内固定术治疗，比较两组治疗效果。结果:微创组术后引流量、术中出血量、住院时间、切口长度低于开放组(n P<0.05)；术后微创组Cobbs角低于开放组，椎体前缘高度、椎体矢状面指数均高于开放组(n P<0.05)；术后微创组功能障碍指数(ODI)及视觉模拟评分法(VAS)评分低于开放组(n P<0.05)；微创组并发症总发生率低于开放组(n P<0.05)。n 结论:Sextant微创经皮椎弓根螺钉内固定术与开放式手术相比，患者创伤较少，住院时间较短，疼痛症状较轻，且并发症较少，更利于机体功能恢复。“,”Objective:To compare the clinical effects of Sextant minimally invasive percutaneous pedicle screw fixation and open pedicle screw fixation in the treatment of thoracolumbar multiple spine fractures.Methods:A total of 60 patients with thoracolumbar multiple spine fractures from July 2016 and July 2019 were enrolled, the patients were randomly divided into open group (28 cases) and minimally invasive group (32 cases). The open group were treated with open pedicle screw fixation, and the minimally invasive group were treated with Sextant minimally invasive percutaneous pedicle screw fixation.The therapeutic effects of the two groups were comparatively analyzed.Results:The minimally invasive group had significantly less postoperative drainage volume and intraoperative blood loss, and significantly shorter hospital stay and incision length than the open group (n P<0.05). After surgery, the minimally invasive group had significantly smaller Cobbs angle but significantly higher anterior vertebral height and vertebral sagittal index than the open group (n P<0.05). After surgery, the minimally invasive group had lower Oswestry disability index (ODI) and visual analogue scale (VAS) scores than the open group (n P<0.05). The total incidence of complications in minimally invasive group was lower than that in open group (n P<0.05).n Conclusions:Compared with open surgery, Sextant minimally invasive percutaneous pedicle screw fixation has characteristics of less trauma, shorter hospital stay, milder pain and fewer complications, which is more conducive to body functional recovery.