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通过巯基乙酸与异烟酰腙的亲核加成 ,再经分子内酰胺化反应合成了一系列 3-异烟酰胺基 -2 -烃基噻唑啉 - 4-酮类化合物 ,其结构经元素分析和 1H NMR确认。室内生物活性研究表明 ,化合物IIc和 IIh在 5 0 mg/L浓度下对葡萄白腐病 Coniothyrium diplodiella(Speg.) Sace离体相对抑制百分数达 80 %。
A series of 3-isonicotinamido-2-alkylthiazoline-4-ones were synthesized by the intramolecular amidation reaction of thioglycolic acid with isonicotinoyl hydrazone. The structure was characterized by elemental analysis and 1H NMR confirmed. The indoor bioactivity studies showed that the relative inhibition percentage of compounds IIc and IIh to grape white rot Coniothyrium diplodiella (Speg.) Sace was 80% at the concentration of 50 mg / L.