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早在1768年,Heberden就怀疑冠状动脉痉挛(简称CAS)与心绞痛有一定关系,1870年由Latham首次明确提出CAS是心绞痛发作的原因,此观点一直盛行到二十世纪初。以后CAS的理论逐渐被人们忽视并摒弃。因为在冠状动脉造影时,患者需常规含服硝酸甘油,故造影中很少发现CAS;另外,病理学医师在心肌梗塞患者尸解中发现了严重的冠状动脉内粥样硬化,因而认为粥样硬化引起的冠状动脉狭窄是冠心病唯一的病理学基础,并错误地认为冠状动脉明显增厚,管壁硬化后不可能再发
As early as 1768, Heberden suspected that coronary artery spasm (CAS) had some relationship with angina pectoris. For the first time, Latham made it clear in 1870 that CAS was the cause of angina pectoris. This view prevailed until the early twentieth century. After CAS’s theory gradually been ignored and abandoned. Because coronary angiography in patients with conventional nitroglycerin to be required, it is rarely found in the imaging CAS; In addition, the pathology physician found myocardial infarction in patients with severe coronary atherosclerosis, so that atherosclerosis Coronary artery stenosis caused by sclerosis is the only pathological basis of coronary heart disease, and wrongly that the coronary artery was significantly thicker, the wall can not be hardened after the recurrence