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目的 :了解四川省狂犬病暴露者狂犬疫苗注射后血清抗体水平。方法 :对四川省 2 7个县 (市、区 )抽样采集狂犬病暴露者疫苗免疫后的血清用间接荧光免疫法进行检测。结果 :75 3份血清中 ,抗体阳性率为 87.91% ,总的抗体几何平均滴度 (GMT)为 18.6 7。不同厂家产品、男女和各年龄组之间的抗体阳性率无显著性差异 ,而不同厂家和年龄段的抗体 GMT值组间有显著性差异 (F=2 .42 2 5 ,P<0 .0 5 ;F=3.492 ,P<0 .0 1) ,以 0～岁组最高 ,年龄越大越低。结论 :开展常规的疫苗免疫后抗体检测 ,酌情增加抗体阴性者和老年暴露者的接种针次 ,以提高免疫成功率具有十分重要的意义
Objective: To understand the level of serum antibody after rabies vaccine injection in rabies exposed area in Sichuan province. Methods: Serum samples were collected from rabies-exposed rabies vaccines in 27 counties (cities and districts) in Sichuan Province by indirect immunofluorescence assay. Results: Among 753 serum samples, the positive rate of antibody was 87.91%, and the total geometric mean antibody titer (GMT) was 18.67. There was no significant difference in the positive rate of antibody between different manufacturers and between men and women and all age groups, but there was a significant difference between the antibody GMT values of different manufacturers and age groups (F = 2.4225, P <0. 0 5; F = 3.492, P <0.01), the highest in 0 ~ group, the older the lower. CONCLUSIONS: It is of great significance to carry out conventional antibody testing after vaccination and to increase vaccination doses of antibody-negative and elderly patients as appropriate, so as to improve the success rate of immunization