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目的观察冠心病 (CHD)患者血清载脂蛋白AⅠ (ApoAⅠ )、载脂蛋白B(ApoB)与血浆D 二聚体 (DD)水平的变化特点 ,并探讨其相关性。方法CHD患者 12 4例和 2 6例正常对照组采用免疫散射比浊法测定ApoAⅠ、ApoB浓度 ,ELISA法测定DD水平。结果CHD患者中 ,急性心肌梗死 (AMI)和不稳定型心绞痛 (UAP)组患者ApoB浓度、DD水平均显著高于对照组 (P <0 .0 1) ;陈旧性心肌梗死 (OMI)和稳定型心绞痛 (SAP)组患者ApoB浓度高于对照组 ,ApoAⅠ浓度低于对照组 (P <0 .0 1) ,但DD水平无改变 (P >0 .0 5 )。 12 4例CHD患者相关分析显示 :ApoB与DD呈显著正相关 ,ApoAⅠ与DD呈显著负相关 (P <0 .0 0 1)。结论冠心病患者存在载脂蛋白代谢异常 ,AMI、UAP组患者DD水平增高 ,且载脂蛋白与DD有密切关系。
Objective To observe the changes of serum apolipoprotein AⅠ (ApoAⅠ), apolipoprotein B (ApoB) and plasma D dimer (DD) levels in patients with coronary heart disease (CHD) and to explore its correlation. Methods The levels of ApoA Ⅰ and ApoB in 12 4 CHD patients and 26 normal controls were measured by immunomagnetic nephelometry. The level of DD was measured by ELISA. Results The levels of ApoB and DD in patients with acute myocardial infarction (AMI) and unstable angina pectoris (UAP) were significantly higher than those of the control group (P <0.01), and those of old myocardial infarction (OMI) and stable The level of ApoB in SAP group was higher than that in control group, while the ApoAI level in SAP group was lower than that in control group (P <0.01), but there was no change in DD level (P> 0.05). Correlation analysis showed that there was a significant positive correlation between ApoB and DD in 12 4 CHD patients, and a significant negative correlation between ApoA Ⅰ and DD (P <0.01). Conclusions There is abnormal apolipoprotein metabolism in patients with coronary heart disease. The levels of DD in patients with AMI and UAP are increased, and apolipoproteins are closely related to DD.