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以 T_d 值为溶出参数,用均匀设计法筛选处方,转篮法测定溶出度。按最佳处方制备骆驼蓬总生物碱胶囊(Ⅰ)并与总生物碱浸膏胶囊(Ⅱ)和总生物碱片剂(Ⅲ)比较,经方差分析,三种剂型 T_d、T_(50)均有显著性差异(P<0.01)。
The T_d value is the dissolution parameter, the prescription is screened by the uniform design method, and the dissolution rate is determined by the basket method. The total alkaloid capsules of Peganum harmonii (I) were prepared according to the best prescription and compared with total alkaloid extract capsules (II) and total alkaloid tablets (III). After analysis of variance, the three formulations T_d and T_(50) were all There was a significant difference (P<0.01).