Two alkaloids tylophoridicine D (1) and tylophoridicine E (2) have been isolated from Tylophora atrofolliculata. The structures of the compounds were elucidated on the basis of spect -roscopic analysis. Two alkaloids tylophoridicine D (1) and tylophoridicine E (2) have been isolated from Tylophora atrofolliculata. The structures of the compounds were elucidated on the basis of spect -roscopic analysis.