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目的 :观察 AT1 受体拮抗剂氯沙坦 (L os)对家兔髂动脉球囊损伤新生内膜的影响。方法 :家兔 30只 ,随机分为 3组 :对照组 (Con组 )、试验组 (L os组 ,30 mg· kg- 1 · d- 1 )、卡托普利组 (Cap组 ,30 mg· kg- 1 · d- 1 )。 1wk后行髂动脉球囊损伤手术 ,wk5取髂动脉测定内膜面积。结果 :L os组新生内膜面积 (0 .0 97± 0 .0 19) mm2较 Con组 [(0 .16 9± 0 .0 32 ) mm2 ,P<0 .0 1]和 Cap组 [(0 .12 3± 0 .0 2 4) m m2 ,P<0 .0 5 ]均明显减少。结论 :L os对兔髂动脉球囊损伤所致的内膜增生有明显抑制作用
Objective: To observe the effect of AT1 receptor antagonist losartan on neointimal hyperplasia in rabbits with iliac artery balloon injury. Methods: Thirty rabbits were randomly divided into three groups: control group (Con group), experimental group (L os group, 30 mg · kg -1 · d -1), captopril group (Cap group, 30 mg · Kg -1 · d -1). 1wk iliac artery balloon injury surgery, wk5 iliac artery to determine the intima area. RESULTS: The neointimal area (0.97 ± 0.019) mm2 in L os group was significantly higher than that in Con group [(0.169 ± 0.322) mm2, P <0.01] and [ 0 .12 3 ± 0 .0 2 4) m m2, P <0. 05] were significantly reduced. Conclusion: L os has significant inhibitory effect on intimal hyperplasia induced by rabbit balloon iliac artery injury