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目的探讨氨磺必利和氯氮平分别合并碳酸锂治疗女性躁狂发作的临床疗效.方法选择2011年7月至2012年7月我院精神科收治的72例女性躁狂症患者随机分为研究组和对照组治疗8周,研究组采用氨磺必利合并碳酸锂进行治疗;对照组采用氯氮平合并碳酸锂进行治疗.于治疗前和第1、2、4、8周末以 Bech-Rafaelsen 躁狂量表(BRMS)评定病情的严重程度,耐受性的评价采用不良反应量表(TESS)及相关辅助检查.结果两组治疗前后 BRMS 评分差异均有统计学意义(P<0.05),两组治疗有效率当,研究组不良反应发生率明显低于对照组(P<0.05).结论氨磺必利合并碳酸锂与氯氮平合并碳酸锂治疗女性躁狂发作总体有效率相当,但氨磺必利合并碳酸锂不良反应较轻,治疗依从性好,更适用于治疗女性急性躁狂发作患者.“,”Objective: To investigate the amisulpride and clozapine combined with lithium in the clinical efficacy of the treatment of women with manic episodes.Method: Select 2011 July 2012 our hospital psychiatric admitted 72 cases of female patients with mania were randomly divided into treatment for eight weeks of the study group and the control group, the study group was treated with amisulpride treatment combined with lithium;control group using clozapine combined with lithium treatment. Before treatment and 1,2,4,8 weekend Bech-Rafaelsen Mania Rating Scale (BRMS) assess the severity of the disease, tolerance evaluation of adverse reaction scale (TESS) and laboratory examinations. Results: two groups before and after treatment BRMS score differences were statisticaly significant (P <0.05), treatment in the two groups when the study group incidence of adverse reactions was significantly lower than the control group (P <0.05). Conclusion: amisulpride Lee combined with lithium and clozapine combined with lithium in the treatment of women overal efficiency quite manic, but combined with lithium amisulpride the lighter adverse reactions, treatment compliance, and more applicable to the treatment of women with acute patients with manic episodes.