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目的:探讨肺癌患者C反应蛋白和血小板-单核细胞聚集体与血栓前状态的关系及其应用价值。方法:以免疫比浊法、流式细胞仪以及血凝分析仪分别检测60例初诊肺癌患者,35例肺良性疾病患者和30例健康对照者血浆C反应蛋白(CRP)、血小板-单核细胞聚集体(PMA)、血小板p-选择素(CD62p)、纤维蛋白原(FIB)、D-二聚体(D-D)以及抗-凝血酶-Ⅲ(AT-Ⅲ)水平。结果:肺癌患者CRP,PMA,FIB,D-D,CD62p水平显著高于而AT-Ⅲ显著低于肺良性疾病和健康对照者(P<0.01或P<0.001)。CRP和PMA平行阳性以及有转移的肺癌患者FIB,D-D和CD62p水平分别显著高于CRP和PMA均正常以及无转移的患者(P<0.001)。CRP,PMA,CD62p及CRP+PMA在肺癌患者中的敏感度分别为85.0%,81.7%,88.3%及90.0%。CRP和PMA与FIB,D-D和CD62p均呈显著正相关(P<0.01或P<0.001)。结论:CRP和PMA与血栓前状态有密切联系,在判断肺癌患者病情中具有重要的意义。CRP可以作为监测肺癌患者体内血栓前状态以及血栓形成的独立指标。
Objective: To investigate the relationship between C-reactive protein and platelet-monocyte aggregates and prothrombotic state in patients with lung cancer and its clinical value. Methods: Immunoturbidimetric assay, flow cytometry and hemagglutination analyzer were used to detect the plasma levels of C-reactive protein (CRP), platelet-mononuclear cells (PBMCs) in 60 newly diagnosed lung cancer patients, 35 pulmonary benign disease patients and 30 healthy controls. (PMA), platelet P-selectin (CD62p), fibrinogen (FIB), D-dimer (DD) and anti-thrombin-III (AT- Results: The levels of CRP, PMA, FIB, D-D and CD62p in patients with lung cancer were significantly higher than those in patients with benign lung disease and healthy controls (P <0.01 or P <0.001). The levels of FIB, D-D and CD62p in CRP and PMA parallel positive and metastatic lung cancer patients were significantly higher than those in normal and non-metastatic CRP and PMA patients (P <0.001). The sensitivity of CRP, PMA, CD62p and CRP + PMA in patients with lung cancer were 85.0%, 81.7%, 88.3% and 90.0%, respectively. There was a significant positive correlation between CRP, PMA and FIB, D-D and CD62p (P <0.01 or P <0.001). Conclusions: CRP and PMA are closely related to the prethrombosis state, which is of great significance in judging the status of patients with lung cancer. CRP can be used as an independent indicator of prothrombotic state and thrombus formation in lung cancer patients.