论文部分内容阅读
肝硬化是各种慢性肝病发展到晚期的一种病理改变,肝功能损害、门静脉高压是其突出的表现。近年来,血管活性物质对肝脏疾病影响的研究已成为一个热点,特别是内皮素(ET)和一氧化氮(NO)。ET和NO是血管内皮细胞产生的生物调节因子,ET是由内皮细胞产生的一种多肽,具有缩血管和扩血管作用,而NO为一种强有力的血管内皮细胞舒张因子,具有强烈扩张血管作用。实验证实ET和NO与肝硬化的发生密切相关。
Cirrhosis is a pathological change in the development of various chronic liver diseases to late stage, liver damage, portal hypertension is its outstanding performance. In recent years, studies on the effects of vasoactive substances on liver diseases have become a hot spot, especially endothelin (ET) and nitric oxide (NO). ET and NO are biological regulators produced by vascular endothelial cells. ET is a polypeptide produced by endothelial cells and has vasoconstrictive and vasodilative effects. NO is a potent vasodilator of vascular endothelial cells and has a strong dilation of blood vessels effect. Experiments confirmed that ET and NO are closely related to the occurrence of cirrhosis.