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第三军医大学第三附属医院陈东风等于1988年至1990年,使用特异性的心钠素(CN)抗体,以放射免疫方法检测,经病理学、影像学及其它生化检查证实的良恶性腹水各40例患者的腹水、血浆CN水平,并计算腹水CN/血浆CN的比值(似下简称比值)。恶性腹水组腹水CN水平为1439.2±607.4ng/L(X±SD)、比值为2.97±1.09,良性腹水组为322.0±141.4和0.50±0.16,两组差异非常显著(P<0.01)。将腹水CN水平600ng/L作标准判断良、恶性腹水的诊断指标,敏感性90％,特异性92.5％,准确性91.25％,阳性预检值92.3％,阴性预检值90％,阳性拟然比12,阴性拟然比0.108,用比值1.0作标准的诊断指标分别
Chen Dongfeng, the Third Affiliated Hospital of the Third Military Medical University, from 1988 to 1990, used specific atrial natriuretic peptide (ANP) antibodies to detect radioimmunoassay, benign and malignant ascites confirmed by pathology, imaging and other biochemical tests 40 patients with ascites, plasma CN levels, and ascites CN / plasma CN ratio (hereinafter referred to as the ratio). The level of CN in malignant ascites group was 1439.2 ± 607.4ng / L (X ± SD), the ratio was 2.97 ± 1.09. The benign ascites group was 322.0 ± 141.4 and 0.50 ± 0.16, the difference was significant (P <0.01). The ascites CN level 600ng / L as a criterion for the diagnosis of benign and malignant ascites diagnostic indicators, the sensitivity of 90%, specificity 92.5%, accuracy 91.25%, positive pretest value of 92.3%, negative pretest value of 90% positive Than 12, negative than expected 0.108, with the ratio of 1.0 for the standard diagnostic indicators respectively