【摘 要】
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Spinal cord injury (SCI) elicits a robust inflammatory re-sponse that is a hallmark of the secondary injury mecha-nisms. Neuroinflammation is orchestrated initi
【机 构】
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Department of Physiology and Pathophysiology, the Regenerative Medicine Program, the Spinal Cord Res
论文部分内容阅读
Spinal cord injury (SCI) elicits a robust inflammatory re-sponse that is a hallmark of the secondary injury mecha-nisms. Neuroinflammation is orchestrated initially by the response of resident astrocytes and microglia to injury, which subsequently facilitates the recruitment of peripheral immune cells into the SCI lesion (Orr and Gensel, 2018). This inflammatory response contributes to cell death and tissue degeneration through the production of pro-inflam-matory cytokines and chemokines, free radicals and proteo-lytic enzymes. However, neuroinflammatory cells also play beneficial regulatory role in repair mechanisms after SCI by adopting a reparative and wound healing phenotype (Orr and Gensel, 2018; Tran et al., 2018). Hence, understanding the underlying mechanisms by which immune cells are reg-ulated within the microenvironment of injury would aid in hessing the reparative potential of inflammation follow-ing SCI.
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