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Background: Liver cirrhosis is associated with immune deficiency, which causes these patients to be sus- ceptible to various infections, including cryptococcus infection. Mortality in cirrhotic patients with cryp- tococcosis has increased. The present study was to explore the risk factors of mortality and the predictive ability of different prognostic models. Methods: Forty-seven cirrhotic patients with cryptococcosis at a tertiary care hospital were included in this retrospective study. Data on demographics, clinical parameters, laboratory exams, diagnostic meth- ods, medication during hospitalization, severity scores and prognosis were collected and analyzed. Stu- dent\'s t test and Mann-Whitney test were used to compare characteristics of survivors and non-survivors at a 90-day follow-up and cerebrospinal fluid (CSF) manifestations of cryptococcal meningitis. Multivari- ate Cox regression analysis was used to identify the independent risk factors for mortality. Kaplan-Meier curves were used to analyze patient survival. Receiver operating characteristic (ROC) curves were used to evaluate the different prognostic factors. Results: The 30- and 90-day survival rates were 93.6％ and 80.9％, respectively, in cirrhotic patients with cryptococcosis. Cryptogenic liver diseases [hazard ratio (HR) = 7.567, 95％ confidence interval (CI): 1.616-35.428, P = 0.010], activated partial thromboplastin time (APTT) (HR = 1.117, 95％ CI: 1.016-1.229, P = 0.022) and Child-Pugh score (HR = 2.146, 95％ CI: 1.314-3.504, P = 0.002) were risk factors for 90- day mortality in cirrhotic patients with cryptococcosis. Platelet count (HR = 0.965, 95％ CI: 0.940-0.991, P = 0.008) was a protective factor. APTT (HR = 1.120, 95％ CI: 1.044-1.202, P = 0.002) and Child-Pugh score (HR = 1.637, 95％ CI: 1.086-2.469, P = 0.019) were risk factors for 90-day mortality in cirrhotic pa- tients with cryptococcal meningitis. There was significant difference in the percentage of lymphocytes in CSF between survivors and non-survivors [60.0 (35.0-75.0) vs. 95.0 (83.8-97.2), P < 0.001]. The model of end-stage liver disease-sodium (MELD-Na) score was more accurate for predicting 30-day mortality both in patients with cryptococcosis [area under curve (AUC): 0.826, 95％ CI: 0.618-1.000] and those with cryptococcal meningitis (AUC: 0.742, 95％ CI: 0.560-0.924); Child-Pugh score was more useful for predict- ing 90-day mortality in patients with cryptococcosis (AUC: 0.823, 95％ CI: 0.646-1.000) and those with cryptococcal meningitis (AUC: 0.815, 95％ CI: 0.670-0.960). Conclusions: These results showed that cryptogenic liver diseases, APTT and Child-Pugh score were as- sociated with mortality in cirrhotic patients with cryptococcosis and cryptococcal meningitis. MELD-Na score was important for predicting 30-day mortality, and Child-Pugh score was critical for predicting 90- day mortality.