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业已知道,即使完全没有饮酒史的患者,亦可见到类似酒精性肝炎的肝脏损害。有报告提到,高度肥胖或糖尿病的中年妇女,空—回肠旁路术和小肠广泛切除术后的患者,其肝脏组织检查,可见到脂肪变性,有Mallory小体和汇管区周围纤维化及肝细胞气球样变性等酒精性肝炎的组织学表现。体内酒精的来源,除饮酒之外,作为内因性来源,是由肠管内细菌所产生,正常人其产量极微,而在肠管内细菌增殖的情况下,由肠管内细菌产生的酒精则可增加。已有报告提及有关肠管内生酒精及考虑与其相关的肝脏损害。1973年Klipstein报告热带斯泼卢患者,增殖的肠内细菌可产生酒精。此后于1975年Peters及
It is known that liver damage similar to alcoholic hepatitis can be seen even in patients with no history of alcohol consumption. There are reports that middle-aged women with a high degree of obesity or diabetes, patients undergoing empty-ileum bypass surgery and extensive excision of the small intestine may have steatotic findings of liver tissue with Mallory bodies and fibrosis surrounding the portal area and Hepatocellular Balloon Degeneration and other histological manifestations of alcoholic hepatitis. The source of body alcohol, in addition to alcohol, as a source of internal causes is produced by bacteria in the intestine, the output of normal people is minimal, and in the case of bacterial proliferation in the intestine, the alcohol produced by intestinal bacteria can increase . There have been reports mentioning about intestinal endogenous alcohol and considering liver damage associated therewith. In 1973, Klipstein reported tropical splenopulu patients, proliferation of intestinal bacteria can produce alcohol. Since then Peters and 1975