STAT3基因是近年来发现的凋亡抑制基因,具有抑制凋亡和参与细胞周期调控的双重功能。研究报道证明,在基础和临床实验中STAT3基因与放、化疗的敏感性有着密切的关系。因而目前研究关注于以STAT3基因为靶点的基因治疗,尤其是RNA干扰技术抑制STAT3基因的表达,增加肿瘤的自发性凋亡和放、化疗诱导的凋亡,抑制肿瘤生长,提高肿瘤对放、化疗的敏感性。 STAT3 gene is found in recent years, apoptosis inhibitor, with the dual function of inhibiting apoptosis and participating in cell cycle regulation. Research reports show that in basic and clinical trials STAT3 gene and radiotherapy and chemotherapy are closely related to the sensitivity. Therefore, the present study focuses on gene therapy targeting STAT3 gene, especially RNA interference technology, which inhibits the expression of STAT3 gene, increases the spontaneous apoptosis of the tumor and induces apoptosis by radiotherapy and chemotherapy, inhibits the growth of the tumor, Chemotherapy sensitivity.