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目的：探讨药物利用评估( DUE)模式在抗菌药物专项整治实践中的应用。方法：按照DUE的基本步骤,采用回顾性方法收集资料,对某实践单位进行万古霉素的DUE实践并根据评价结果改善临床用药模式。结果：该院万古霉素使用的合理性得到提高,DUE评价使用理由和关键病程指征方面的指标大多有明显改善,尤其在适应证和用药指征方面的合格率由79.5%提高到95.0%；抗菌药物分级管理方面的合格率由63.3%提高到92.7%；给药频率合格率由72.5%提高到96.0%。结论：DUE作为一种较新的临床药学工作模式和医疗质量持续改进方案,在实践单位的运行获得良好的效果,促进了万古霉素的合理使用。“,”Objective:To investigate the application of drug utilization evaluation( DUE) as a kind of clinical pharmacy work model in the antibacterial drug special rectification. Methods: Following the steps of DUE schedule,retrospective method was conducted to collect the data of the use of vancomycin in one institution and the model of clinical drug use was improved by the evaluation result. Re-sults:The rationality of vancomycin use was improved in the institution. The index of drug use reasons and key disease course indica-tors was improved significantly. The qualification rate of indications and drug indications was increased from 79. 5% to 95. 0%,and the qualification rate of antibacterial drugs classification management was increased from 63. 3% to 92. 7%. The qualification rate of dosing frequency was increased from 72. 5% to 96. 0%. Conclusion:As a program for continual improvement of new clinical pharmacy work mode and medical care quality,the mode plays an important role in the institution and improves the rational use of vancomycin.