To study the cardiac protective effects of tetramethylpyrazine (TMP) on patients undergoing cardiac operation. Methods: Twelve patients with rheumatic heart disease were randomly divided into the TMP group and the control group, 6 in each group,and 3mg/kg TMP was given to the TMP group. The changes of hemodynamics, serum creatine phosphokinase (CPK), creatine phosphokinase isoenzyme (CPK MB) levels were observed before, during and 72 hours after operation. Results: The hemodynamic indexes in the TMP group were better than those in the control group after operation, the serum CPK, CPK MB levels measuring 12 h, 24 h and 48 h after operation in the TMP group were lower than those in the control group. Conclusion:TMP has good cardiac protective function in patients undergoing cardiac operation in improving cardial function and reducing the release of myocardial enzymes. To study the protective effects of tetramethylpyrazine (TMP) on patients undergoing cardiac operation. Methods: Twelve patients with rheumatic heart disease were randomly divided into the TMP group and the control group, 6 in each group, and 3 mg/kg TMP was given to The TMP group. The changes of hemodynamics, serum creatine phosphokinase (CPK), creatine phosphokinase isoenzyme (CPK MB) levels were observed before, during and 72 hours after operation. Results: The hemodynamic indexes in the TMP group were better than those in the The control group after operation, the serum CPK, CPK MB levels measuring 12 h, 24 h and 48 h after operation in the TMP group were lower than those in the control group. Conclusion: TMP has good protective function in patients undergoing cardiac operation in Improving cardial function and reducing the release of myocardial enzymes.