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目的探讨脊髓亚急性联合变性的病因、临床表现特点及治疗方法。方法回顾分析12例脊髓亚急性联合变性患者临床表现,分析实验室检查资料及给予维生素B12治疗的疗效。结果12例均有后索、侧索及周围神经损害。大多数病例血清维生素B12降低,肌电图示周围神经损害。脑与脊髓MRI呈现白质脱髓鞘改变。维生素B12治疗有效率为91.7%。结论脊髓亚急性联合变性是由于维生素B12缺乏所致的后索、侧索及周围神经损害为主的疾病,早诊断、早治疗是关键。
Objective To investigate the etiology, clinical manifestations and treatment of subacute combined degeneration of spinal cord. Methods The clinical manifestations of 12 patients with spinal cord subacute combined degeneration were analyzed retrospectively. The laboratory test data and the efficacy of vitamin B12 treatment were analyzed. Results All 12 cases had posterior cable, lateral cable and peripheral nerve damage. Serum vitamin B12 is reduced in most cases and EMG is peripheral nerve damage. Brain and spinal cord MRI showed white matter demyelination changes. The effective rate of vitamin B12 treatment was 91.7%. Conclusions Subacute combined degeneration of the spinal cord is a disease characterized by posterior cable, lateral cord injury and peripheral nerve damage caused by vitamin B12 deficiency. Early diagnosis and early treatment are the key points.