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目的 探讨支气管哮喘患儿肾脏受损情况。方法 采用速率免疫散射比浊法和化学显色终点法分别测定 6 6例轻、中、重度支气管哮喘急性发作期患儿的尿视黄醇结合蛋白 (RBP)、白蛋白 (Alb)、转铁蛋白 (TRF)、免疫球蛋白G(IgG)和N 乙酰 β D 氨基葡萄糖苷酶 (NAG)含量 ,并与 32例正常儿童对照组对照。 结果 轻、中、重度哮喘患儿尿RBP、Alb、TRF、NAG含量均高于对照组 (均P <0 0 1) ,尿IgG含量与对照组差别无显著性意义(P >0 0 5 )。尿RBP、NAG含量重度哮喘患儿高于轻、中度哮喘患儿 (均P <0 0 5 ) ,轻度与中度哮喘患儿差别无显著性意义 (均 P >0 0 5 )。尿TRF、Alb含量在轻、中、重度哮喘患儿差别均无显著性意义 (均 P >0 0 5 )。结论 支气管哮喘患儿急性发作期存在肾小球和肾小管轻度或早期损害。
Objective To investigate the renal damage in children with bronchial asthma. Methods The rate of urinary retinol binding protein (RBP), albumin (Alb) in 66 children with mild, moderate and severe bronchial asthma at the early stage of acute bronchial asthma were measured by rate nephelometry and chemical end - (TRF), immunoglobulin G (IgG) and N-acetyl-D-glucosaminidase (NAG) were measured and compared with 32 healthy children. Results The urinary RBP, Alb, TRF and NAG in children with mild, moderate and severe asthma were significantly higher than those in the control group (all P <0.01), while there was no significant difference in urine IgG between the two groups (P> 0.05) . Urinary RBP and NAG levels in children with severe asthma were significantly higher than those in mild and moderate asthma children (all P <0.05). There was no significant difference between mild and moderate asthmatic children (all P> 0.05). Urinary TRF, Alb content in mild, moderate and severe asthma children were no significant difference (all P> 0.05). Conclusions There is glomerular and tubular mild or early damage in children with bronchial asthma during acute attack.