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在天然产物的全合成中,常用经典的消旋拆分法以获得一个所需的对映异构体。但这种方法还同时得到一个相等最不需要的对映异构体,因此至少要损失50%,因为分离的产率不可能是100%,所以损失会更多。手征性全合成的方法则不同,它在手征性试剂的存在下,能使无手征性或原手征性的原料,完全转变成所需的对映异构体。这样不经过拆分,即得到光学活性产物,而且产率高,是一种经济的合成方法。它已成
In the total synthesis of natural products, the classical racemization method is often used to obtain the desired enantiomer. However, this method also results in an equal and most unwanted enantiomer at the same time, so at least a 50% loss is required because the yield of separation can not be 100%, so the loss will be more. The method of total chiral synthesis is different, it can be in the presence of chiral reagents, can make achiral or chiral raw material, completely converted into the desired enantiomer. In this way, the optically active product is obtained without resolution, and the yield is high, which is an economical synthesis method. It has become