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在一九九九年八月版的《自然医学》(Nature Medicine)期刊上,美国研究人员Mark Feitelson及其同事发表文章报告,他们已经成功地建立第一个由乙肝病毒(HBV)所致的慢性肝炎的转基因动物模型。他们将HBV的DNA引入称为严重综合性免疫缺陷(SCID)的小鼠,并用正常的免疫系统移植到该小鼠体内,使其终生自我产生HBV,但又可将HBV看
In the August 1999 edition of Nature Medicine, an article by American researcher Mark Feitelson and colleagues reported that they have succeeded in establishing the first hepatitis B virus (HBV) Transgenic animal model of chronic hepatitis. They introduced HBV DNA into mice called Severe Comprehensive Immunodeficiency (SCID) and transplanted into the mice with the normal immune system, allowing them to self-produce HBV throughout their lifetime,