目前临床上使用的各类传统化疗药物对许多人类恶性肿瘤 (包括白血病等血液肿瘤 )的治疗效果有限 ,或是毒副作用太大 ,使其临床应用受到限制。近年来 ,一类新型的白血病化疗药物—组蛋白去乙酰化酶抑制剂 (ＤＡＩＳ)在国内外受到广泛关注 ,有些药物已进入Ⅰ /Ⅱ期临床试验。这预 At present, all kinds of traditional chemotherapy drugs used clinically have limited therapeutic effect on many human malignancies (including hematological tumors such as leukemia) or have too large toxic or side effects, which limits their clinical application. In recent years, a new class of leukemia chemotherapeutic drugs, histone deacetylase inhibitors (DAIS) are widely concerned at home and abroad, and some drugs have entered phase Ⅰ / Ⅱ clinical trials. This pre-