三尖杉酯碱和高三尖杉酯碱是新型的抗肿瘤生物碱。对细胞蛋白质合成有明确的抑制作用。其性质稳定、毒性较小,对非淋巴细胞性白血病、红白血病和真性红细胞增多症有显著疗效。本文就两药的抗瘤谱、作用原理、药代动力学、临床应用和主要不良反应作一简要介绍。 Harringtonine and homoharringtonine are novel antitumor alkaloids. On cell protein synthesis has a clear inhibitory effect. Its stable nature, less toxic, non-lymphocytic leukemia, erythroleukemia and polycythemia have a significant effect. This article on the anti-tumor spectrum of two drugs, the principle of action, pharmacokinetics, clinical applications and major adverse reactions for a brief introduction.