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目的 :评估肾移植供者中肾小动脉玻璃样变 (arteriolehyalinosis ,AH)、肾小动脉硬化 (arteriolosclerosis,AS)及全球性肾小球硬化 (glomerulosclerosis,GS)的发生率 ,探讨三者间的关系及年龄对AH和AS的影响。 方法 :测量零时供肾肾活检标本中肾小动脉的管壁和肾小动脉面积 ,两者比值为AS指数 (indexofarteriolosclerosis,IA)。按Banff标准分为AH0 、AH1及AH2 三级 ,分析IA与AH相关性。按GS %严重程度将患者分为四组 ,组Ⅰ、Ⅱ、Ⅲ、Ⅳ的GS %分别为 0、0～ 10 %、10 %～ 30 %及 30 %～ 5 0 % ,分析四组患者IA差异。 结果 :IA为 0 76± 0 0 4(n =89)。46 %的标本有AH ,44 %的标本有全球性GS ,GS的百分比为 (6± 10 ) %。IA与年龄正相关 (r=0 430 6 ,P <0 0 0 0 1)。AH0 、AH1、AH2 患者的平均年龄分别为 (30 6± 15 5 )岁、(4 0 5± 15 5 )岁及 (5 0 0± 13 2 )岁 ,其IA分别为 0 73± 0 0 3、0 78± 0 0 3及 0 80± 0 0 3。AH0 与AH1及AH0 与AH2 患者间的年龄及IA均显著不同。四组中IA分别为 0 75±0 0 4、0 76± 0 0 3、0 77± 0 0 4及 0 80± 0 0 1,组Ⅰ与组Ⅳ及组Ⅱ与组Ⅳ间IA显著不同。 结论 :肾移植供者中常有AH及GS ,AH与AS随年龄增加而加重 ,AS与GS可能有相同的病理
Objective: To evaluate the incidence of arteriole hyalinosis (AH), arteriolosclerosis (AS) and global glomerulosclerosis (GS) in renal allograft recipients, Relationship and Age Influences on AH and AS. Methods: The area of the renal arterioles and the area of the renal arterioles at the time of zero-hour renal biopsy were measured. The ratio of the two indexes was AS (indexofarterolosclerosis, IA). By Banff standard is divided into AH0, AH1 and AH2 three, analysis of IA and AH correlation. According to the severity of GS%, the patients were divided into four groups. The GS% of groups Ⅰ, Ⅱ, Ⅲ and Ⅳ were 0,0 ~ 10%, 10% ~ 30% and 30% ~ 50% respectively. difference. Results: IA was 0 76 ± 0 0 4 (n = 89). 46% had AH, 44% had global GS, and the percentage of GS was (6 ± 10)%. IA was positively correlated with age (r = 0 430 6, P <0 0 0 0 1). The average age of AH0, AH1 and AH2 patients were (30 6 ± 15 5) years, (40 ± 15 5) years and (5 0 0 ± 132) years, respectively. The IA were 0 73 ± 0 0 3 , 0 78 ± 0 0 3 and 0 80 ± 0 0 3. There was a significant difference in age and IA between AH0 and AH1 and between AH0 and AH2. IA in the four groups were 0 75 ± 0 0 4,0 76 ± 0 0 3,0 77 ± 0 0 4 and 0 80 ± 0 0 1, respectively. IA in group Ⅰ and group Ⅳ and group Ⅱ and group Ⅳ were significantly different. CONCLUSION: AH and GS are often found in renal transplant recipients, AH and AS increase with age, AS and GS may have the same pathology