论文部分内容阅读
目的:探讨6-氧-甲基鸟嘌呤-DNA甲基转移酶(MGMT)和P53在脑胶质瘤中的表达及意义。方法:采用免疫组化法检测133例肿瘤组织中MGMT蛋白和P53蛋白的表达情况,分析MGMT和P53与胶质瘤临床病理特征、预后及两者之间的相互关系。结果:不同级别胶质瘤间MGMT阳性表达率差异无统计学意义(P=0.158);MGMT阳性表达水平差异也无统计学意义(P=0.138),但MGMT表达水平与患者生存时间密切相关(P=1.07×10-6)。不同级别胶质瘤间P53阳性表达率差异无统计学意义(P=0.306),而表达水平则在胶质瘤不同级别间差异有显著统计学意义,且呈正相关关系(r=0.187,P=0.032);P53表达水平与患者生存时间密切相关(P=2.08×10-14);MGMT和P53间无相关性(P=0.065)。结论:MGMT蛋白表达与胶质瘤病理分级无明显关系,P53蛋白表达水平与胶质瘤病理分级有关,两者都与生存时间密切相关。
Objective: To investigate the expression and significance of 6-O-methylguanine-DNA methyltransferase (MGMT) and P53 in glioma. Methods: The expressions of MGMT protein and P53 protein in 133 tumor tissues were detected by immunohistochemistry. The clinicopathological characteristics, prognosis and the relationship between MGMT and P53 and glioma were analyzed. Results: There was no significant difference in the expression of MGMT between different grades of gliomas (P = 0.158). There was also no significant difference in the expression of MGMT (P = 0.138), but the expression of MGMT was closely related to the survival time P = 1.07 × 10 -6). There was no significant difference in the expression of P53 between different grades of gliomas (P = 0.306), but there was a significant difference between the different grades of gliomas (r = 0.187, P = 0.032). The expression level of P53 was closely related to the survival time of patients (P = 2.08 × 10-14). There was no correlation between MGMT and P53 (P = 0.065). Conclusion: The expression of MGMT protein is not related to the pathological grade of glioma. The expression of P53 protein is related to the pathological grade of glioma, both of which are closely related to the survival time.