肝纤维化是各种肝病发展为肝硬化的必由途径。目前临床上对肝纤维化的诊断仍以病理检查为主,但病理检查为有创性检查,病人难以接受;肝活检部位又有其局限性,且难以进行动态观察。因此寻找一种无创伤,又能进行动态观察肝纤维化程度的血清学诊断指标是目前国内外研究的重点课题之 Liver fibrosis is the only way to develop cirrhosis of liver disease. At present, the clinical diagnosis of liver fibrosis is still the main pathological examination, but pathological examination for invasive examination, the patient is difficult to accept; liver biopsy site has its limitations, and difficult to observe dynamically. Therefore, looking for a noninvasive, but also for the dynamic observation of the degree of liver fibrosis diagnostic serological indicators is the focus of research at home and abroad