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目的:探讨多肿瘤标志物蛋白芯片诊断系统对原发性肝癌的诊断价值.方法:采用多肿瘤标志物蛋白芯片诊断系统,检测分析73例原发性肝癌(PHC)患者、48例良性肝病患者和40例健康对照者血青的12种常见肿瘤标志物,包括糖原199(CA199)、甲胎蛋白(AFP)、神经原特异性烯醇化酶(NSE)、游离前列腺特异抗原(f-PSA)、癌胚抗原(CEA)、前列腺特异抗原(PSA)、糖原242(CA242)、糖原125(CA125)、糖原153(CA153)、铁蛋白(FER)、人生长激素(HGH)和β-人绒毛膜促性腺激素(B-HCG).结果:PHC组AFP,CA199,CA125,CEA,CA242,FER和β-HCG的阳性检出率分别为65.7%,49.3%,45.2%,21.9%,19.1%,41.1%和6.8%,与良性肝病组(25.0%,31.3%,22.9%,4.2%,6.3%,29.2%,0)比较均显著增高(P<0.01或P<0.05).AFP的诊断效率在单项指标中居首位(79.6%),AFP+FER和AFP+FER+CA125的诊断效率最高(均为83.9%).结论:AFP,FER,CA125是肝癌联合诊断的理想指标,其联合检测有利于提高PHC的诊断率.
Objective: To investigate the diagnostic value of multiple tumor marker protein chip diagnostic system for primary hepatocellular carcinoma.Methods: The multi-tumor marker protein chip diagnostic system was used to detect and analyze 73 cases of primary liver cancer (PHC) and 48 cases of benign liver disease And 40 healthy controls, including 12 glycogen markers (CA199), AFP, NSE, f-PSA , Carcinoembryonic antigen (CEA), prostate specific antigen (PSA), glycogen 242 (CA242), glycogen 125 (CA125), glycogen 153 (CA153), ferritin (FER), human growth hormone (HGH) Results: The positive rates of AFP, CA199, CA125, CEA, CA242, FER and β-HCG in PHC group were 65.7%, 49.3%, 45.2% and 21.9 %, 19.1%, 41.1% and 6.8%, respectively, were significantly higher than those in benign liver disease group (25.0%, 31.3%, 22.9%, 4.2%, 6.3%, 29.2%, 0) (P <0.01 or P <0.05). The diagnostic efficiency of AFP was the highest (79.6%) in single index, and the diagnostic efficiency of AFP + FER and AFP + FER + CA125 were the highest (83.9%). Conclusion: AFP, FER and CA125 are the ideal indexes for combined diagnosis of hepatocellular carcinoma Joint detection is conducive to improve the diagnosis of PHC Rate.