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目的探讨前哨淋巴结活检阴性的早期乳腺癌患者，在保乳术中仅行前哨淋巴结活检替代传统腋窝清扫的临床应用价值。方法45例早期乳腺癌患者分为A、B组，A组行传统腋窝清扫，B组仅行前哨淋巴结活检。比较两组患者术后并发症及复发的发生情况。结果45例中43例成功保乳，成功率95.6%。A组18例，B组25例。B组的并发症均比A组少，差异有统计学意义。两组随访均未发现复发转移的病例。结论对于经验丰富的团队，在保乳术中，对于前哨淋巴结阴性的患者，用前哨淋巴结活检替代传统腋窝清扫是安全的。“,”Objective To investigate the clinical application value of sentinel lymph node biopsy replacing the traditional axillary dissection in patients with sentinel lymph node negative during breast-conserving surgery. Methods 45 cases of early stage breast cancer patients were divided into group A and B. Patients in group A underwent conventional axillary dissection, those in group B underwent sentinel lymph node biopsy only. Comparison of the postoperative complications and recurrence were taken between these two groups of patients. Results among the 45 cases, 43 cases were successful underwent breast conservation surgery;the success rate was 95.6%. Group A contains 18 cases, group B contains 25 cases. The complications in group B were less than the A group, the difference was statistically significant. Recurrence and metastasis were not found in the two groups followed up. Conclusion for the experienced team, patients with sentinel lymph node negative are safe to use sentinel lymph node biopsy to replace traditional axillary dissection in breast-conserving surgery.