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葡萄球菌蛋白A(Staphylococcal protein A,简称SPA)系大多数金黄色葡萄球菌细胞壁的成分之一,能与人及多种哺乳动物血清中IgG的Fc段(IgG3例外)发生非特异性结合,在琼脂凝胶中呈现沉淀线,但并不影响Fab段的活性。故可用已知抗体标记SPA阳性菌株来检测未
Staphylococcal protein A (SPA) is one of the components of most of the Staphylococcus aureus cell wall and can non-specifically bind to the Fc portion of IgG (except IgG3) in human and various mammalian sera. Precipitates appear in the gel but do not affect the activity of the Fab segment. Therefore, known antibodies can be used to detect SPA-positive strains