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为了解正常人卵泡液（ＦＦ）中胰岛素样生长因子Ⅱ（ＩＧＦ－Ⅱ）的浓度及其与性激素、促性腺激素、胰岛素的关系，探讨ＩＧＦ－Ⅱ在正常卵泡发育中的作用。对２２例月经周期正常妇女的２６个卵泡期卵泡（周期第７～１７ｄ）ＦＦ内ＩＧＦ－Ⅱ、Ｅ２、Ｐ、Ｔ、ＬＨ、ＦＳＨ、ＩＮＳ以及部分病例血清标本中ＩＧＦ－Ⅱ浓度进行了放免检测，分析血清与 ＦＦ ＩＧＦ－Ⅱ浓度及ＦＦ ＩＧＦ－Ⅱ与性激素、促性腺激素、胰岛素之间的关系。结果发现：ＦＦ ＩＧＦ－Ⅱ浓度与血清之间无相关性（Ｐ＞０．０５），与卵泡大小，周期天数，ＦＦ Ｅ２、ＩＮＳ浓度呈正相关（Ｐ＜０．０５），与 ＦＦ ＬＨ／ＦＳＨ呈负相关（Ｐ＜０．０５）。提示ＩＧＦ－Ⅱ是人卵巢自分泌的调节因子，对卵泡的发育起一定作用。
To investigate the relationship between IGF-Ⅱ and sex hormones, gonadotrophin and insulin in normal human follicular fluid (FF) and explore the role of IGF-Ⅱ in normal follicle development. IGF-Ⅱ, E2, P, T, LH, FSH, INS in serum of FF of 26 follicular follicles (cycles 7-17d) of 22 women with normal menstrual cycle were excluded from the study The serum and FF IGF-Ⅱ concentrations and the relationship between FF-IGF-Ⅱ and sex hormones, gonadotropin and insulin were detected and analyzed. The results showed that there was no correlation between the concentration of FF-II and serum (P> 0.05), but positively correlated with the follicle size, number of days, FF E2 and INS concentration (P <0.05) Was negatively correlated (P <0.05). Tip IGF-Ⅱ is a regulator of human ovarian autocrine, the development of follicles play a role.